The Panthera bloodline came from a creature from the panthera genus (lion, tiger, jaguar, leopard, or snow leopard) who contracted vampirism by the original vampiric infected bat.
There are five vampire bloodlines from five different species who contracted vampirism by an infected bat centuries ago. The five bloodlines are Panthera the panther, Serpentes the snake, Desmodus the bat, Crocodilia the crocodile, and Aotidae the monkey. These five vampire bloodlines make up the Houses of Valemont University, tho Desmodus House burnt down years ago and since there were no known Desmodus vampires left, it was not rebuilt.
-Spoilers Alert- Edit
The Panthera House hosts an annual Panthera Halloween party. It's invite only and no freshman (first year students at the university) are allowed. Sebastian and Leonardo are members of the Panthera House on campus.